Therapeutics

Dr Jonathan Kuo: Ketamine Therapy, Peptides and Longevity Innovations

by Dr Thomas Paloschi

Episode #1

Published: 9 August 2025

Read Time: 9:25

This episode explores the emergence of interventional longevity medicine as a distinct clinical discipline. Dr. Jonathan Kuo shares how his background in anesthesiology and high-volume interventional pain management evolved into regenerative medicine, nervous system modulation, peptide therapy, blood-based therapeutics, mitochondrial diagnostics, and AI-assisted care.

Rather than discussing longevity as lifestyle advice alone, this conversation focuses on direct physiological interventions aimed at restoring cellular function, autonomic balance, metabolic health, and resilience against chronic disease.

 

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We discuss:

1
Introduction & the state of longevity medicine [00:00];
2
Clinical background: chronic pain and mental health [02:25];
3
Interventional mental health & Neuro Reset (stellate ganglion block) [03:21];
4
The Longevity Pyramid & MEDS framework (Mental, Exercise, Diet, Sleep) [04:36];
5
Ketamine therapy: safety, stigma, and clinical use [05:17];
6
Patient experience & post-ketamine integration [07:28];
7
Interventional longevity & regenerative medicine [10:00];
8
Peptides: categories, stacking, and anti-aging benefits [10:55];
9
Blood therapeutics: plasmapheresis, ozone, and EBOO [11:50];
10
Gene therapy & follistatin for muscle growth [25:50];
11
Mitochondrial diagnostics & cellular medicine [28:43];
12
AI, wearables, and the future of longevity medicine [37:14];

Show Notes:

Interventional Longevity Medicine: From Peptides and Blood Therapeutics to Mitochondria, Gene Therapy, and AI

Guest: Dr. Jonathan Kuo
Host: Dr. Thomas Paloschi
Location: Dr. Longevity Studio, Milan

Episode Summary

This episode explores the emergence of interventional longevity medicine as a distinct clinical discipline. Dr. Jonathan Kuo shares how his background in anesthesiology and high-volume interventional pain management evolved into regenerative medicine, nervous system modulation, peptide therapy, blood-based therapeutics, mitochondrial diagnostics, and AI-assisted care.

Rather than discussing longevity as lifestyle advice alone, this conversation focuses on direct physiological interventions aimed at restoring cellular function, autonomic balance, metabolic health, and resilience against chronic disease.

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